Thoroughly updated and completely rewritten to explain the latest advances in the biology of cardiac function, the fifth Edition of this internationionally acclaimed classic provides a comprehensive review of the heart's performance in health and disease. Written by a single author with more than 50 years experience in both basic science and clinical medicine, this book describes the interrelationships between hemodynamic physiology, cardiac muscle function, and the cellular air and molecular mechanisms that determine the contractile and electrical behavior of the heart. This information, illustrated by figures designed by the author, is then used to explain the pathophysiology of clinical arrhythmias, ischemic heart disease, and heart failure.
• Comprehensive descriptions of the physiology, biochemistry, and molecular biology of cardiac contraction and the electrical activity of the heart
• Clinically oriented discussions of the pathophysiology of heart disease, including the molecular mechamsms that cause arrhythmias, ischemic heart disease, and heart failure
• Expert authorship by a recognized authority with more than a half century s experience as a clinician. teacher, academic cardiologist, physiologist and biochemist
• A lucid and easy to understand style that bridges the gap between basic science and clinical medicine; between bench and bedside
• More than 500 illustrations, most prepared by the author, that detail the structural, physiological, biophysical, biochemical, and molecular mechanisms of heart disease